Dr. Bhavani Shankara Bagepally
“A Magnetic Resonance Diffusion Tensor Imaging study in Alzheimer’s Dementia”
PhD work includes comprehensive evaluation Alzheimer's Dementia (Clinical & neuropsychiatry symptoms, Cognitive functions, Genetic risk factor and Neuro-imaging). Study explores the role of genetic risk factor, ApoE gene polymorphism on brain white matter structural connectivity using Diffusion Tensor Imaging.
Guide: Dr. Mathew Varghese, Professor of Psychiatry,
Co Guide: Dr John P. John   Additional Professor of Psychiatry.
Other research interests:

Education:
Current Position:
Publications:




































































































































































Email ID:
Neuroimaging in Neurodegenerative diseases: Alzheimer’s and other dementias, Movement disorders:  Essential Tremors, Progressive Supranuclear palsy, Neuroimaging in epilepsy.
MBBS, at Sri Devraj Urs Medical College, Tamaka, Kolar, Karnataka, (from 2001 to 2007)
PhD scholar in Clinical Neurosciences (ICMR funded) 
(Scopus Author ID: 34867754400)
Number of Publications:  13 (International journals = 13, National journals = 0)
[Research articles: 7, Letter to Editor: 1, Conference proceedings: 3, E-letters: 2] +                   currently under review =3.
Number of Conference Abstracts/Presentations = 17 + 2 (International = 9, National = 8)

List of research publications (Journals): (in chronological order)
  1. Kota, L. N., Shankarappa, B. M., Shivakumar, P., Sadanand, S., Bagepally, B. S., Krishnappa, S. B., Purushottam, M., et al. (2012). Dementia and Diabetes Mellitus: Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India. International Journal of Alzheimer’s disease, 2012, 1–4. doi:10.1155/2012/702972
  2. Prakash, O., & Bagepally, B. S. (2012). Catatonia and mania in patient with AIDS: treatment with lorazepam and risperidone. General Hospital Psychiatry. doi:10.1016/j.genhosppsych.2012.01.010, PMID: 22361355 (In Press)
  3. Saini J, Bagepally BS, Bhatt MD, Chandran V, Bharath RD, Prasad C, Yadav R, Pal PK. (2012) “Diffusion Tensor Imaging: Tract Based Spatial Statistics study in Essential Tremor”  Submitted to Parkinsonsonism and Related Disorders. PMID: 22297126 (In Press)
  4. Saini J, Bagepally BS, Sandhya M., Pasha SA, Yadav R, & Pal PK. (2012). In vivo evaluation of white matter pathology in patients of progressive supranuclear palsy using TBSS. Neuroradiology. doi:10.1007/s00234-011-0983-7, PMID: 22160214 (In Press)
  5. Bagepally BS, Bhatt MD, Chandran V, Saini J, Bharath RD, Vasudev M, Prasad C, Yadav R, Pal PK. (2012). Decrease in Cerebral and Cerebellar Gray Matter in Essential Tremor: A Voxel-Based Morphometric Analysis under 3T MRI. Journal of Neuroimaging. doi:10.1111/j.1552-6569.2011.00598.x, PMID: 21447032 (In Press)
  6. Bagepally, B.S., Halahalli, H. N., John, J. P., Kota, L., Purushottam, M., Mukherjee, O., Sivakumar, P. T., et al. (2012). Apolipoprotein E4 and Brain White Matter Integrity in Alzheimer’s disease: Tract-Based Spatial Statistics Study under 3-Tesla MRI. Neuro-Degenerative Diseases, 10 (1-4), 145–148. doi:10.1159/000334761
  7. Bharath S, Purushottam M, Mukherjee O, Bagepally BS, Prakash O, Kota L., Krishnappa S B, Sivakumar PT, Jain S, Varghese M. (2010). Apolipoprotein E polymorphism and dementia: a hospital-based study from southern India. Dementia and Geriatric Cognitive Disorders, 30(6), 455-460. doi:10.1159/000322093, PMID: 21252538
  8. Bagepally BS, John JP, Kovoor JME, Purushottam M, Mukherjee O, Kota L, Sadananda S, Prakash O, Sivakumar PT, Bharath S, Jain S, Varghese M. (2010). Diffusion tensor imaging in Alzheimer’s dementia and APOE-[epsilon] 4 status. Alzheimer’s and Dementia, 6(4, Supplement 1), S18-S19. doi:16/j.jalz.2010.05.051
  9. Bagepally, B. S., & Prakash, O. (2009). Nonsignificant weight gain with atypical antipsychotics in men with Alzheimer’s disease: an important result of the CATIE-Alzheimer’s disease study. The American Journal of Psychiatry, 166(9), 1063-1064; author reply 1064-1065. doi:10.1176/appi.ajp.2009.09040544, PMID: 19723796.
  10. Sinha S, Saini J, Bagepally BS, Ramachandraiah TC, Prasad C, Tally AB, Satishchandra P. "Focal Structural Abnormalities in Juvenile Myoclonic Epilepsy: A Voxel-Based DTI Study" Epilepsia, 52(Suppl. 6):23–263, 2011, p172-173, doi: 10.1111/j.1528-1167.2011.03207.x
  11. Pal, P., Pasha, S. A., Sandhya, M., Yadav, R., Saini, J., Bagepally, B. S., & Gupta, A. (2012). Correlation of Midbrain atrophy with Quantitative balance impairment in Progressive Supranuclear Palsy. Parkinsonism & Related Disorders, 18, Supplement 2(0), S47. doi:10.1016/S1353-8020(11)70261-9
  12. Bagepally B. "Memory performance is related to amyloid and tau pathology in the hippocampus: a Response" Journal of Neurology Neurosurgery Psychiatry, E-letter Published online on July-24 2009.
  13. Bagepally B., Long-term effects of the concomitant use of memantine with cholinesterase inhibition in AD: a Response, Journal of Neurology Neurosurgery and Psychiatry, E-letter, online published on July-1 2009.

List of Scientific Manuscripts submitted to the Journals: Currently under review Process
  1. Saini J, Sinha S, Bagepally BS, Ramchandraiah CT, Thennarasu K,  Prasad C, Taly AB, Satishchandra P  “Subcortical structural abnormalities in Juvenile myoclonic epilepsy (JME): MR volumetry and vertex based analysis” (Currently under Review Process)
  2. Saini J, Sinha S, Bagepally BS, Ramchandraiah CT, Thennarasu K, Prasad C, Taly AB, Satishchandra P “White matter abnormalities in Juvenile Myoclonic Epilepsy: A Diffusion Tensor Imaging study” (Currently under review Process).
  3. Saini J, Bagepally BS, Sandhya M., Pasha SA, Yadav R, Thennarasu K & Pal PK Subcortical Structures in Progressive Supranuclear Palsy: Vertex Based Analysis. (Submitted to European Journal of Neurology)

Abstracts Presented at Conferences: (Chronological order)
  1. Bagepally BS, John JP, Kota L, Sivakumar PT, Purushottam M, Mukherjee O, Jain S, Bharath S, Varghese M. “Altered White matter Connectivity & Atrophy at Hippocampal Sub-regions in Alzheimer's Dementia and ApoE4 carriers” POSTER PRESENTATION at Alzheimer's Association International Conference, to be held in Vancouver, British Columbia, Canada, July 14-19, 2012. (To be presented)
  2. Rakesh B, Bagepally BS, Bharath S, Saini J, Sadananda S, Donthi NK, Sivakumar PT, Chandra SR, Varghese M. " Cognitive decline and regional brain perfusion in Alzheimer’s disease using Single Photon Emission Computer Tomography - a retrospective study". POSTER PRESENTATION at Alzheimer's Association International Conference, to be held in Vancouver, British Columbia, Canada, July 14-19, 2012. (To be presented)
  3. Bagepally BS, Rakesh B “Consciousness, Gender and Ageing: An exploratory resting state fMRI study” at POSTER PRESENTATION at International Conference on Looking Within: Interdisciplinary Approaches to Consciousness. 5th to 7th January, 2012, Bangalore.
  4. Pal P, Pasha S.A., Sandhya M, Yadav R, Saini J, Bagepally B.S., Gupta A."Correlation of midbrain atrophy with quantitative balance impairment in progressive supranuclear palsy" POSTER PRESENTATION at XIX World Congress on Parkinson’s Disease and Related Disorders, 11th to 14 th December 2011 Shanghai, China.
  5. Bagepally BS, John JP, Varghese M, Halahalli HN, Kota L, Sadananda S, Sivakumar PT, Bharath S, Jain S. "Cognitive Correlates of Gray matter atrophy in Alzheimer’s dementia: Voxel Based Morphometric study using 3-Tesla MRI" (Oral Presentation) at Alzheimer's and Related Society of India (ARDSI) XVIth National Conference, 26th & 27th of Nov.2011, Pune.
  6. Rakesh B, Bagepally BS, Bharath S, Saini J, Sadananda S, Donthi NK, Sivakumar PT, Chandra SR, Varghese M. "Brain perfusion in Alzheimer’s disease using Single-photon emission computed tomography - a retrospective study". (Oral Presentation) at Alzheimer's and Related Society of India (ARDSI) XVIth National Conference, 26th & 27th of Nov.2011, Pune.
  7. Saini J, Sinha S, Bagepally BS, Ramachandraiah C, Tally AB, Satishchandra P. "Thalamic structural abnormalities in Juvenile Myoclonic Epilepsy:  Surface wise and Voxel Based Morphometric analysis using 3T MRI", POSTER PRESENTATION at 14th Annual Conference - Indian Society of Neuroradiology - 22nd September to 25th September 2011 at Chandigarh.
  8. Jadav R, Sinha S, Saini J, Tally AB, Bagepally BS. "Diffusion Tensor Imaging in Wilson's disease", POSTER PRESENTATION, at 19th Annual Conference of the Indian Academy of Neurology-IANCON 2011, 22nd to 25th September 2011, Pune.
  9. Bagepally BS, John JP, Varghese M, Halahalli HN, Kota L, Sadananda S, Sivakumar PT, Bharath S, Jain S "Neuroanatomical Correlates of Subcortical structures and Corpus callosum with Neuropsychiatric symptoms in Alzheimer's Dementia" (Oral Presentation), at 8th International Congress of the International Neuropsychiatry Association (IAN-2011). 16th to 18th 2011, Chennai. Awarded First Best Oral Presentation Award
  10. Rakesh B, Bagepally BS, Kota L, Purushottam M, Mukherjee O, John JP, Bharath S,  Sivakumar PT Jain S, Varghese M "An exploratory study to examine the relationship between ApoE4, 5HTTlpr, COMT, gsk, histyr genes on Subcortical volumes in Alzheimer’s Dementia and controls." POSTER PRESENTATION at 8th International Congress of the International Neuropsychiatry Association (IAN-2011). 16th to 18th 2011, Chennai. Awarded Second Best Poster Presentation Award
  11. Sinha S, Saini J, Bagepally BS, Ramachandraiah TC, Prasad C, Tally AB, Satishchandra P. "Focal structural abnormalities in juvenile myoclonic epilepsy: a voxel-based DTI study" POSTER PRESENTATION, at 29th  International Epilepsy Congress, 28th August to 1st  September 2011, Rome, Italy,.
  12. B.S. Bagepally, J.P. John, H. Halahalli, M. Purushottam, O. Mukherjee, L. Kota, S. Sadananda, O. Prakash, P.T. Sivakumar, S. Bharath, S. Jain, M. Varghese “Apo-E4 and Brain white matter integrity in Alzheimer’s disease: A Tract Based Spatial Statistics (TBSS) study under 3T MRI” (Oral Presentation) at Alzheimer’s Disease and Parkinson’s Disease (AD-PD) 10th International Conference held at Barcelona, Spain, From 9th-13th March.
  13. B. Bagepally , J. John1 , M. Purushottam , O. Mukherjee , L. Kota , S. Sadananda , N. Reddy  , O. Prakash , P. Sivakumar, S. Bharath, S. Jain, M. Varghese “Vertex-wise analysis of sub-cortical structures in Alzheimer’s & ApoE4 states” presented (Oral Presentation) at Alzheimer’s Disease Interaction (ADI)-2011 International conference at Toronto, Canada from 26th to 29th March 2011.
  14. Bhavani Shankara Bagepally, Lakshminarayanan .K, Naveen Kumar, Nagendra Prasad, Prasun Gupta, Sivakumar P.T., Srikala Bharath, Mathew Varghese, “Clinical characteristics of Late Onset Psychosis: Data from Geriatric Clinic, NIMHANS ” POSTER PRESENTATION, Presented at NIMRCPSYCON 2010 Conference on held on 6th and 7th March 2010 Bangalore.
  15. Bhavani Shankara Bagepally, Lakshminarayanan .K, Krishna Prasad .M, Suresh Kumar R, Srinivas B.K, Meera Purushottam, Odity Mukherjee, Om Prakash, Sivakumar P.T., Srikala Bharath, Sanjeev Jain, Mathew Varghese “Apo lipoprotein E Gene Polymorphism in Dementias: Data from Geriatric Clinic setting, South India” POSTER PRESENTATION at Alzheimer's and Related Diseases Society of India (ARDSI) - XV National Conference: Held Kolkata from 4th to 6th Dec 2009.
  16. Krishna Prasad M., Bhavani Shankara B, Lakshminarayan K, Suresh Kumar R, Srinivas B.K, Meera Purushottam, Odity Mukherjee, Om Prakash, Sivakumar P.T, Srikala Bharath, Sanjeev Jain, Mathew Varghese “Neuropsychiatric symptoms & Apo lipoprotein E Gene Polymorphism in Dementias: Data from a Geriatric Clinic, South India” POSTER PRESENTATION, Presented at ANCIPS-2010 62nd Annual National Conference of Indian Psychiatric Society held from 17th – 20th January 2010. Jaipur.

Abstracts accepted at Conferences:

  1. Bagepally B.S,, John J.P., Kovoor J.M.E, Purushottam M., Mukherjee O., Kota L.,, Sadananda S., Prakash O., Sivakumar P. T., Bharath S,, Jain S., Varghese M., " Diffusion Tensor Imaging in Alzheimer’s dementia and Apo E4 status "  at International Conference of Alzheimer's (ICAD) 2010 held at Honolulu, Hawaii, United States of America.
  2. Bhavani Shankara B, Lakshminarayanan K, Om Prakash, Sivakumar P.T, Srikala Bharath, Mathew Varghese “Behavioural and psychological symptoms in dementia: Data from tertiary care setting, South India” 9TH SONA Conference, December 8th -13th 2009 Sharma EL Sheikh – Egypt.
  3. Lakshminarayanan K, Bhavani Shankara B, Suresh Kumar R, Srinivas B.K, Meera Purushottam, oddity Mukherjee, Om Prakash, Sivakumar P.T, Srikala Bharath, Sanjeev Jain, Mathew Varghese, “Disease phenotypes in First degree relatives of Apo e4 genotype carrying Dementia cohort.” ARDSI- XV National Conference: Held at Kolkata from 4th to 6th Dec 2009.
bshankara@gmail.com